EFFECT OF ETHANOLIC LEAF EXTRACT OF Solanum torvum ON THE LIPID PROFILE OF MONOSODIUM GLUTAMATE – TREATED
ALBINO WISTAR RATS

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ABSTRACT

The effect of ethanolic leaf extract of Solanum torvum on the lipid profile of monosodium  glutamate – treated rats was investigated. Twenty (20) adult male Albino wister rats were used for the analysis. They were divided into four (4) groups of five rats each. Group I was the normal group and was fed with normal feed and water. Group II was the test control administered with (0.5g/kg) of monosodium glutamate, feed and water, Group III was administered with (250mg/kg) of the leaf extract and 0.5g/kg of monosodium glutamate, and Group IV administered with (500mg/kg) of the leaf extract and 0.5g/kg monosodium glutamate. The rats were housed and subjected to the feed, leaf extract, MSG and water, for 28 days after which they were sacrificed, after an overnight fast, and blood collected by cardiac puncture and used for serum preparation for subsequent analysis of the various parameters. There was no significant change (p > 0.05) in triacylglycerols and VLDL cholesterol in all the groups when compared with the normal and test groups. However, there were significant decreases (p < 0.05) in serum total cholesterol, HDL – cholesterol, and LDL – cholesterol in group 3 and group 4 when compared with the normal and test control. These shows that Solanum torvum leaf extract at the result doses administered may be able to modulate the lipid profile thereby ameliorating the effect of monosodium glutamate. 

TABLE OF CONTENTS

Title Page    –        –        –        –        –        –        –        –        –        i

Certification                   –        –        –        –        –        –        –        –        ii

Dedication –        –        –        –        –        –        –        –        –        iii

Acknowledgements        –        –        –        –        –        –        –        iv-v

Abstract      –        –        –        –        –        –        –        –        –        vi

Table of Contents –        –        –        –        –        –        –        –        vii-ix

List of Tables       –        –        –        –        –        –        –        –        x       

CHAPTER ONE: INTRODUCTION               

  1. Background of the Study        –        –        –        –        –        –        1-3   
    1. Aim and Objectives of the Study      –        –        –        –        3-4
    1. Scope and Limitations   –        –        –        –        –        –        4
    1. Significant of the Study           –        –        –        –        –        –        4

CHAPTER TWO: LITERATURE REVIEW  

  • Description of Solanum torvum        –        –        –        –        –        5-6
    • Physical Characteristics of Solanum torvum                  –        –        6-7
    • Pharmacoligcal activities of Solanum torvum                 –        –        8-9
    • Physical activities of Solanum torvum                  –        –        –        9
    • Monosodium Glutamate          –        –        –        –        –        –        10-11
    • Structure and Properties of Monosodium Glutamate    –        11-12
    • Harmful effects of Monosodium Glutamate         –        –        –        12-14
    • Uses of Monosodium Glutamate      –        –        –        –        14-15
    • Lipid Profile         –        –        –        –        –        –        –        15-17
      • Triacylglycerols (TGS)            –        –        –        –        –        17-19
      • High Density Lipoprotein (HDL)      –        –        –        –        19-22
      • Total Cholesterol (TC)            –        –        –        –        –        22-25
      • Very Low Density Lipoprotein (VLDL)     –        –        –        25-27
      • Low Density Lipoprotein (LDL)       –        –        –        –        27-29
    • Significance of Elevated Serum lipid Profile                  –        –        29-32

CHAPTER THREE: MATERIALS AND METHOD

  • Collection of Leaf Sample       –        –        –        –        –        33
    • Preparation of Sample   –        –        –        –        –        –        34-35
    • Grouping and Treatment of Experimental Animals                –        35-36
    • Blood Collection and preservation of Serum       –        –        –        37
    • Biochemical Assay        –        –        –        –        –        –        37
    • Determination of Triacylglycerol      –        –        –        –        37-38
    • Determination of Total Cholesterol –        –        –        –        38-39
    • Determination of High Density Lipoprotein                  –        –        39-41
    • Statistical Analysis        –        –        –        –        –        –        41

CHAPTER FOUR: RESULTS AND DISCUSSION          

  • Results        –        –        –        –        –        –        –        –        42-44
    • Discussion –        –        –        –        –        –        –        –        45-48

CHAPTER FIVE: CONCLUSION AND RECOMMENDATIONS     

  • Conclusion –        –        –        –        –        –        –        –        49
    • Recommendations                   –        –        –        –        –        –        49

References