The objective of the research is to develop a predictive model that can significantly enhance the detection and monitoring performance of Autism Spectrum Disorder (ASD) using four supervised learning techniques. In this study, we applied four supervised-based classification techniques to the clinical ASD data obtained from 704 patients. Then, we compared the four machine learning (ML) algorithms performance across tenfold cross-validation, ROC curve, classification accuracy, F1 measure, precision, recall, and specificity. The analysis findings indicate that Support Vector Machine (SVM) achieved the uppermost performance than the other classifiers in terms of accuracy (85%), f1 measure (87%), precision (87%), and recall (88%). Our work presents a significant predictive model for ASD that can effectively help the ASD patients and medical practitioners.