TANDEM AMINATION CATALYSIS IN THE SYNTHESIS OF DIAZAPHENOXAZINE COMPOUNDS OF PHARMACEUTICAL INTEREST

Post Views: 4 ABSTRACT The synthesis and characterization of five new linear diazaphenoxazine compounds is reported. The key intermediate, 3-chloro-1-9-diazaphenoxazine, was prepared via a base catalyzed reaction of 2-amino-3-hydroxypyridine with 2,3,5-trichloropyridine in aqueous 1, 4-dioxane. Five 3-amino derivatives of the key intermediate were prepared via Buchwald – Hartwigamination coupling reaction between 3-chloro-1,9-diazaphenoxazine and various heterocyclic…Read More

SYNTHESIS OF NHETEROARYL SUBSTITUTED

Post Views: 15 CHAPTER ONE 1.1       INTRODUCTION The basic sulphonamide group –SO2NH- occurs in various biological active compounds including antimicrobial drugs, antithyroid agents, antitumor antibiotics and inhibitors of carbonic anhydrase1,2.  Sulphonamides are widely used to treat microbial infection by inhibiting the growth of gram-negative and gram-positive bacteria, some protozoa and fungi3. Clinically, sulphonamides are used…Read More

SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL STUDIES OF 4-ACYLPYRAZOLONE COMPLEXES OF SOME d-BLOCK ELEMENTS

Post Views: 10 CHAPTER ONE 1.0       Introduction Investigation on 4-acyl-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one (4-acylpyrazol-5-one) and its transition metal complexes has attracted significant attention because of their applications as extractants1, antipyretic2, analgesic3, antitubercular4, antimycobacterial5, antibacterial6, antifungal7, and antineoplastic8 drugs. 4-acylpyrazol-5-one, is an enolizable ligand with strong ligating ability. These ligands are synthesized by direct acylation at C – 4…Read More

SYNTHESIS, CHARACTERIZATION AND SOLVENT EXTRACTION STUDIES OF 3,5-BIS[(2-HYDROXY-BENZYLIDENE)-AMINO]-BENZOIC ACID AND ITS Co(II) AND Ni(II) COMPLEXES

Post Views: 12 CHAPTER ONE INTRODUCTION 1.0     General Introduction Extraction is the transfer of a solute from one phase to another. Common reasons to carry out an extraction in chemistry are to isolate or concentrate the desired analyte or to separate it from species that would interfere in the analysis. The most common case is…Read More

SYNTHESIS AND EVALUATION FOR BIOLOGICAL ACTIVITIES OF NPYRIDIN

Post Views: 13 ABSTRACT In this study, a series of N-pyridin-3-yl substituted [phenylsulphonamido] acetamide has been synthesized. The reaction of phenylsulphonyl chloride with various amino acids in basic medium yielded phenylsulphonamido alkanoic acid which, on chlorination with thionyl chloride, gave acid chloride derivatives of phenylsulphonamido alkanoic acid in situ. The acid chloride derivatives on condensation with…Read More

SYNTHESIS AND CHARACTERIZATION OF ZINC OXIDE NANOWIRE

Post Views: 9 ABSTRACT Zinc Oxide (ZnO) nanowires with hexagonal structure were successfully synthesized by chemical bath deposition technique. The obtained nanowires were characterized by scanning electron microscope (SEM), X-ray diffraction (XRD), energy dispersive X-ray analysis (EDX) and spectrophotometer. The SEM micrographs revealed the morphology of ZnO nanowires with diameter between 170.3 and 481nm and…Read More

SYNTHESIS AND CHARACTERIZATION OF ZEOLITE AND ITS APPLICATION IN ADSORPTION OF NICKEL FROM AQUEOUS SOLUTION

Post Views: 9 ABSTRACT The synthesis and characterization of zeolite and its application in adsorption of nickel from aqueous solution was investigated. Synthesis of zeolite was performed at 90 oC for 8 h. The size of the resulting crystals increased with an increase in the water content of the reaction mixture. The synthesized zeolite was…Read More

SYNTHESIS AND CHARACTERISATION OF ALKYLATED ISOCYANATE DERIVATIVES OF [Pt2(µ-S)2(PPh3)4]

Post Views: 9 ABSTRACT The highly nucleophilic bridging sulfide centers in bis(μ-sulfido)tetrakis(triphenylphosphine) diplatinum(II), [Pt2(µ-S)2(PPh3)4] enables the incorporation of any organic functionality (R) through facile monoalkylation to form cationic complex [Pt2(µ-S)(µ-SR)(PPh3)4]+. The organic electrophiles; N,N’-(2-dichloroethyl) piperazine-4-carboxi-amine, N-(2-chloroethyl) morpholine-4-carboxi-amine, andN-(2-chloroethyl)-1-methylpiperazine-4-carboxi-amine derived from isocyanate were synthesised by the reactions of piperazine, morpholine and  methyl piperazine respectively with 2-chloroethyl…Read More

SPECTROPHOTOMETRIC DETERMINATION OF PARACETAMOL USING ZIRCONIUM (IV) OXIDE AND AMMONIUM TRIOXOVANADATE (V)

Post Views: 8 ABSTRACT            A simple and sensitive spectrophotometric method for the determination of paracetamol was explored, using zirconium(IV) and vanadium(V) oxides. The method was based on the oxidation of paracetamol by zirconium(IV) and vanadium(V) in  alkaline and acidic media respectively. The stoichiometric studies indicated a mole-ratio of 1:1 for the reactions of paracetamol…Read More

SPECTROPHOTOMETRIC DETERMINATION OF NIACIN, THIAMINE, GLIBENCLAMIDE, ERYTHROMYCIN AND PARA AMINO BENZO IC ACID USING 2, 3 – DICHLORO – 5, 6 – DICYANO – 1, 4 – BENZOQUINONE

Post Views: 13 ABSTRACT A simple and sensitive spectrophotometric method is described for the assay of the drugs; niacin, glibenclamide, erythromycin, thiamine and 4-aminobenzoic acid. The method is based on charge transfer complexation (CT) reaction of niacin, glibenclamide, erythromycin, thiamine and 4-aminobenzoic acid as n-electron donors with 2,3-dichloro-5,6-dicyno-1,4-benzoquinone(DDQ) as л-electron acceptor in methanol. Intensely coloured…Read More

SPECTROPHOTOMETRIC DETERMINATION OF CHROMIUM(III) AND CHROMIUM(VI) USING 2-[E)-[{3-[(2-HYDROXYBENZYLIDENE) AMINO]PHENYL}IMINO)METHYL]PHENOL

Post Views: 17 ABSTRACT The Schiff base ligand, 2-[(E)-[{3–[(2-hydroxybenzylidene)amino]phenyl}imino)methyl]phenol was synthesized by condensing 1,3-diaminobenzene and 2-hydroxybenzaldehyde in absolute ethanol. Its Cr(III) and Cr(VI) complexes were equally synthesized. The ligand was characterized via UV, IR and NMR spectroscopy, whereas the complexes were characterized based on UV and IR spectroscopy and conductivity values. Stoichiometric studies indicated 1:1…Read More

SOLVENT EXTRACTION STUDIES ON Zn(II) AND Cd(II) COMPLEXES OF 1,5-DIMETHYL-2-PHENYL-4[(E)-(2,3,4-TRIHYDROXYPHENYL)]DIAZENYL-1,2-DIHYDROXYL-3H-PYRAZOL-3-ONE

Post Views: 12 TABLE OF CONTENTS Title Page                                                                                                        i Approval Page                                                                                                            ii Certification                                                                                                    iii Dedication                                                                                                       iv Acknowledgement                                                                                            v Table of Contents                                                                                            vi List of figures                                                                                                 xi                                        List of tables                                                                                                   xiii Abstract                                                                                                          xiv 1.         Introduction                                                                                                    1 1.1       The Solvent Extraction Process                                                                      2 1.2       Kinetics…Read More

RISK ASSESSMENT OF SELECTED HEAVY METAL CONTAMINANTS IN PADDY SOIL AND RICE SAMPLES FROM TWO FARMS IN EDDA AFIKPO SOUTH LGA EBONYI STATE NIGERIA

Post Views: 21 CHAPTER ONE 1.0       INTRODUCTION 1.1       Background of study: The study of heavy metals by scientists have intensified over the last two decades, this is partly owing to its usefulness in the preparation of many inorganic complexes, and  even more importantly, because of their health effects as  bio-accumulative toxic materials (Duruibe et al.,…Read More

QUALITY CHARACTERISTICS OF UNDERGROUND WATER RESOURCES IN NKANU EAST AND NKANU WEST LOCAL GOVERNMENT AREAS OF ENUGU STATE, NIGERIA

Post Views: 15 ABSTRACT Physicochemical and bacteriological analyses of underground water resources in Nkanu East and Nkanu West Local Government Areas of Enugu state,  Nigeria were carried out to evaluate the potability and quality of the rural water supplies and to provide baseline data for future quality assessment. Underground water samples were collected from ten…Read More

PRODUCTION, OPTIMIZATION AND APPLICATION OF PRINTING INK FROM WASTE CARBON SOURCES

Post Views: 26 TABLE OF CONTENTS Title page        –           –                 –           –           –           –           i Approval page –           –       –           –           –           –           –           –           ii Certification    –           –           –           –           –  –           –           –           –           iii Dedication      –           –           –  –           –           –           –           –           iv Acknowledgement      –         –           –           –           –           –          …Read More